Ketamine therapy has become a promising treatment for depression, especially for those who haven’t found relief with traditional antidepressants. But one of the most common questions people ask is: How long do the effects last? The answer varies, but here’s what to expect:
- Rapid relief – Many patients experience improvement within hours or days of treatment.
- Short-term effects – A single ketamine session can provide relief for several days to a few weeks.
- Long-term results – A full treatment series and maintenance sessions can extend benefits for months.
- Personal factors play a role – The severity of depression, lifestyle, and follow-up care all influence how long ketamine’s effects last.
Let’s break down what you can expect from a single session, a full treatment series, and ongoing maintenance so you can better understand how ketamine might work for you.
How Does Ketamine Work for Depression?
Unlike traditional antidepressants, which target serotonin, dopamine, or norepinephrine, ketamine acts on glutamate, a neurotransmitter that plays a key role in brain plasticity. This helps the brain form new, healthier neural pathways, allowing for a rapid and often dramatic reduction in symptoms.
While SSRIs and other antidepressants can take weeks to become effective, ketamine can begin working within hours, making it a crucial treatment option for those with treatment-resistant depression or suicidal thoughts.
How Long Do the Effects of a Single Ketamine Session Last?
One of ketamine’s biggest advantages is how quickly it works. However, the duration of symptom relief from a single session is temporary.
Short-Term Effects
- Most patients report improvement in 1 to 24 hours after treatment.
- Relief can last anywhere from a few days to two weeks.
- Dissociative effects, such as feeling detached or “floaty,” wear off within a few hours.
Since the effects of a single treatment are short-lived, most patients require a structured series of sessions to achieve longer-term benefits.
How Long Do the Effects Last After a Full Treatment Series?
Most ketamine treatment plans involve six sessions over 2-3 weeks, followed by maintenance treatments. Completing a full series tends to provide more sustained relief compared to individual treatments.
After a Full Series of Treatments:
- Every patient is different but many patients experience relief for three to five months before requiring a booster session.
- Some individuals report even longer periods of stability with the right maintenance plan.
- Those who continue with regular maintenance treatments tend to have more lasting benefits.
The key to maintaining results is finding the right balance between initial treatment and ongoing maintenance.
What Factors Affect How Long Ketamine’s Effects Last?
Not everyone responds to ketamine the same way. Several factors influence how long the antidepressant effects will last, including:
1. Severity of Depression
People with severe, long-standing depression often need more frequent maintenance treatments compared to those with milder symptoms.
2. Treatment Plan & Maintenance Doses
- A full treatment series typically results in longer-lasting effects than sporadic treatments.
- Regular maintenance sessions help extend ketamine’s benefits.
3. Lifestyle & Mental Health Support
- Therapy, exercise, and mindfulness practices can enhance ketamine’s effectiveness.
- Those who integrate ketamine into a broader mental health plan often experience more lasting relief.
4. Biological Differences
Each person’s brain chemistry, metabolism, and genetics play a role in how long ketamine remains effective.
How Often Will I Need Maintenance Treatments?
Ketamine therapy is not a one-time fix. Most patients need occasional booster sessions to maintain results, but the frequency varies.
Typical Maintenance Schedules:
- Every 2-4 months – Common for individuals with chronic or severe depression.
- Every 6-8 months– For those who experience longer-lasting effects.
- As needed – Some patients only return for a booster if they feel symptoms returning.
A customized maintenance plan can help extend the benefits while minimizing the number of treatments required.
Can Ketamine’s Effects Be Made to Last Longer?
While ketamine alone is powerful, certain strategies can help extend its benefits:
1. Combine Ketamine with Therapy
- Studies show that ketamine combined with psychotherapy improves long-term outcomes.
- Since ketamine enhances emotional openness, therapy may be more effective during this time.
2. Prioritize Sleep, Exercise & Nutrition
- Regular exercise and proper sleep support brain health and mood stability.
- A nutrient-rich diet can further improve mental health.
3. Explore Additional Mental Health Support
- Some patients continue using antidepressants alongside ketamine for added stability.
- Others explore alternative therapies like TMS (Transcranial Magnetic Stimulation) to further support their recovery.
By combining ketamine therapy with lifestyle changes and mental health support, patients often experience longer-lasting relief.
Is Ketamine a Long-Term Solution for Depression?
Ketamine is not a permanent cure for depression, but it can be a life-changing tool. It works by:
- Providing fast relief when other treatments have failed.
- “Resetting” the brain to make it more receptive to therapy and lifestyle changes.
- Helping those with severe depression and suicidal thoughts regain stability.
Long-term success usually requires ongoing care, therapy, and personalized treatment adjustments.
Final Thoughts: Why Choose Anew Therapy?
If you’re considering ketamine therapy for depression, knowing how long the effects last can help you set realistic expectations. The key to sustained relief is finding the right provider and following a structured treatment plan.
At Anew Therapy Utah, we specialize in personalized ketamine treatment for depression, PTSD, and anxiety. Our experienced team provides safe, compassionate care in a supportive environment, helping you navigate every step of the process.Take the next step toward healing—schedule your free intake appointment today and find out if ketamine therapy is right for you.
Searching for the best ketamine clinic in Utah? Anew Therapy offers expert care and proven results. Schedule your free intake appointment today.
