Spravato vs. IM Ketamine
What are the differences?
SPRAVATO® is a nasal spray that has been FDA-approved for individuals with treatment-resistant depression. Ketamine is an injection delivered intramuscularly, that can be used to treat a variety of mental health conditions.
SPRAVATO® (Esketamine) | IM Ketamine Therapy | |
|---|---|---|
Eligibility | Adults with treatment-resistant depression or MDD with suicidal thoughts (must have failed at least two antidepressants) | Broader use for depression, anxiety, PTSD and OCD |
Price | Covered by most insurance carriers | Cash pay, not covered by insurance
|
Route of Administration | Nasal spray (self-administered under supervision) | Intramuscular (IM) injection or intravenous infusion
|
FDA Approval | FDA-approved for treatment-resistant depression | Off-label for mental health conditions but widely used
|
Dosing Frequency | Twice weekly for 4 weeks, then weekly for maintenance | Typically 1-2 times per week, then tapered as needed
|
Monitoring | Requires two-hour observation at our facility | Requires 90-120 minute observation at our facility |
A vibrant life is waiting for you
Our team of mental health experts are excited to meet you.
